3.3 The limb field

This is the last part of “The genetics of vertebrate development”. Not much about most of the features of vertebrates were presented and this last part is about just “the limb field”. There is a lot of interesting papers out there one could read to learn about the subject.
It would be really sad if all you got is what Fleury present in cteappv.

So our physicists “found it impossible to find a description of where the lateral plates come from“. Hopefully this is not the case of all physicists, but one should include in the set of the Google-impotent the ones that reviewed the paper and those of the editorial board that handled it. Vincent Fleury don’t even have the excuse of being Google-impotent, as he consulted an excellent book on developmental biology [111], which he probably didn’t read entirely, or if he read, he failed to understand.

Unfortunately, he isn’t handicapped only when it comes to consult textbooks, he is also unable to get information from PubMed, say about “Collinear activation Hox genes gastrulation mesoderm“. Really bad condition and he lives in a darkness which he thinks is the same where biologists live.

Fleury infers, that people assume the presence of the lateral plate without knowing where it come from. Well, people know quite well where mesoderm originates, there are plenty of studies with demonstrations of fates of epiblastic cells (I mean with real data) and anyway, what scientific paper discuss basic knowledge?

Because Fleury ignores1 where the lateral plate mesoderm come from (and think that biologist ignore it as well) he feel free to imagine where it comes from and he is almost ready to tell us about it; but in the mean time he spent some space to tell us about fin buds adjacent to the neural tube at the telencephalon level, imaginary linear regulation of several FGF family members based on assumed pressure differences, and soon imaginary vortices will come in play.

One could just stop reading at this point, being sure that the whole stuff is so flawed that going through the 41 pages (glossary and references exclude) is a waste of time. I will certainly continue, not only because I promised to do so, but because I find it quite funny and I’m eager to pinpoint other lunacies.

Let me put something straight here: it will be great when we will dispose of a model linking genes’ expression and morphogenesis and physicists contribution is valuable. But Fleury couldn’t do the job, we need physicists able to read and understand.

1. I had a discussion on whether he ignores it in the sense that he didn’t learned about it, or if the just dismissed unconsciously what bothers him, or if it is an intended ignorance. I don’t think that this is an interesting point to discuss, and I will not continue in this path. What is important is the result he presented for publication and the fact that a scientific journal accepted it. This explain why a short discussion was deleted from the comments and transfered in a private forum in which I’m not participating.


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