Oops 090630

vincent fleury: By the way “I can has L2/R2″ is not a sentence Aha! this is not a sentence. I was waiting for this one since I read the paper. For Dr Fleury first step here, and second one here, both necessary to get the flavor. For everybody else, a puzzle served below [p22 col2 [...]

Oops 090619#2

[p21, col 1, §2 Hindlimbs form first during development of most tetrapods, and they are likely to be last to disappear, as known in snakes. The fact that hindlimbs form first and are thus often larger, may be ascribed to the narrow spacing in the caudal part of the early embryo (more below). Ahem, hindlimbs [...]

Oops 090611

Another reference mismatch here: This dorso-ventral polarity is also present in the hands, with an obvious palmar and a dorsal side. Bio-chemically, this difference seems to be related to the genetic pathway of en1 and wnt-7a [62], and analogous genes may be at play in the dorso-ventral polarity of insect wings [33]. But the expression [...]

3 The genetics of vertebrate development

In the third section of the paper Fleury starts to display his incredulity of genetic explanations of developmental morphogenesis, concluding by p16, col2, §2: The review presented here highlights that inductive cascades of unidirectional gradients of scalar quantities cannot explain morphogenesis. The review is incomplete and often bogus,which explain why Fleury is reaching this conclusion. [...]

Quite clear

This is an excerpt from Flery’s paper, p16, column 1. However, Popperl et al.’s article deals mostly with the role of lazarus in the cranial (hindbrain and anterior trunk) compartment, (especially it shows how pbx genes participate in the regulatory loop of hox genes needed to specify rhombomere boundaries in the hindbrain) and when coming [...]

I was wrong

Well, I was dead wrong in fact, when a few weeks ago I was writing: What embryology textbooks our physicist have consulted that doesn’t give the origin of the mesoderm and the subdivisions of the mesodermal plate to paraxial, intermediary and lateral? He should give us the name(s) of the book(s) to avoid it(them).

The invertebrate morphogenesis

The invertebrate morphogenesis The second section of Fleury’s paper is about The invertebrate morphogenesis and the example chosen is Drosophila the fly, which is the most studied of the invertebrates but far from describing the “invertabrates” morphogenesis in general, just take a look at a sponge. Two subsections, The fly bauplan and The homeobox genes.

Oops 090428

Oops 090428 [p6, column 2, §2] These pathways will “induce” either legs, antennas, halteres, or wings along the body by nucleation of appendage primordia at intersections of genetic boundaries. However, wings and halteres are more dorsal (hence the wings “on the back”), while antennas and legs are more ventral (hence legs hanging below the abdomen). [...]

One of the ex cathedra assertions of Vin…

One of the ex cathedra assertions of Vincent Fleury, in a general public forum where his book and theory where discussed, early 20071, was: Je suis désolé de devoir insister : ouvrez vos yeux, ça n’a AUCUN sens d’invoquer la fonction d’un organe, si l’ensemble des modifications possibles d’un animal ne sont pas quelconques. L’influence [...]

Stop the rotatives!

You foolish biologists, stop whatever you’re doing right now and learn from the wisdom of our physicist :